Mitral valve prolapse in children and adolescents

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Mitral valve prolapse appears to be a frequent cardiovascular finding, particularly in young females. Echocardiographic surveys have demonstrated findings of mitral valve prolapse in 6%–10% of normal young women.1 Although well described in adults,2–4 the clinical features of mitral valve prolapse in children and adolescents have seldom been discussed.5–9 In this study, we review the clinical, electrocardiographic (ECG), echocardiographic, and angiographic findings, exercise response, and follow-up history in patients with mitral valve prolapse seen at the Cleveland Clinic who were less than 20 years of age.

Material and methods

Twenty-six patients less than 20 years of age with mitral valve prolapse detected by echocardiography were seen between February 1979 and December 1981 at the Cleveland Clinic. There were 14 females and 12 males whose ages ranged from 3 to 20 years with a mean of 15 years. Of the 26 patients, 4 had Marfan’s syndrome, one forme fruste. Two patients had mitral valve prolapse associated with congenital heart disease; one of these had tetralogy of Fallot and the other had ostium primum atrial septal defect with Down’s syndrome. One patient had anorexia nervosa with mitral valve prolapse. These 7 patients were eliminated from our series to permit concentration on patients with isolated mitral valve prolapse with no obvious secondary abnormality. Thus, our study consisted of 19 patients with isolated mitral valve prolapse whose ages ranged from 6 to 24 years (mean, 16 years). There were 11 females and 8 males, a female/male ratio of 1.4:1.

A detailed . . .



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