Verrucous squamous cell carcinoma of the vagina

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Primary carcinoma of the vagina is an infrequent malignancy of the female genital tract. The overall incidence is between 1% and 2% of all carcinomas of the female genital tract.1

Verrucous carcinoma was classified by Ackerman2 as a distinct variety of squamous cell carcinoma with unique characteristics. The tumor has been recognized in various organs. According to Ramzy et al,3 it was first described by Martens and Tilesius in 1804, and later by Ricord and Traite in 1851. Dawson et al4 stated that Buschke reported large condylomatous penile lesions in 1896. This tumor later became known as giant condyloma acuminatum of Buschke-Loewenstein.5, 6

Verrucous carcinoma has been called massive condylomata acuminata, premalignant condylomata acuminata, carcinoma associated with condylomata acuminata, and well-differentiated squamous cell carcinoma.4, 7 The various diagnoses have contributed to the impression that this variant of squamous cell carcinoma only rarely involves the female genital tract. To date, approximately 40 cases of verrucous carcinoma involving the female genital tract and only 16 neoplasms involving the vagina have been reported.3, 8–14 A case of verrucous carcinoma of the vagina is reported here and the pathology, clinical behavior, and treatment of this unusual neoplasm are discussed.

Case report

A 69-year-old Caucasian woman, gravida 2, para 2, was referred to the Cleveland Clinic for surgical extirpation of a well-differentiated, fungating squamous cell carcinoma of the vagina thought to be verrucous carcinoma. The tumor was discovered 2 months earlier at another hospital. The patient had uterine prolapse for which she had used . . .



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