Progressive coronary artery disease

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Two hundred sixty-two patients with at least one coronary artery obstruction equal to or greater than 50% lumen diameter reduction on the initial study and who underwent repeat cardiac catheterization 2 to 182 months later were studied for progressive arterial changes. Of the 262 patients, 116 men (49%) and 12 women (50%) met the criteria for progression. Risk factors obtained at the time of the initial catheterization in patients who met the criteria for progression were compared to risk factors in those patients who did not. No significant difference could be found between the groups in relation to family history, blood pressure, diabetes, smoking habits, weight, cholesterol, triglycerides, initial electrocardiogram, and initial catheterization findings.

The frequency of detecting progressive arterial changes tended to increase as the interval between studies increased. The frequency of multiple-vessel progression increased as the interval between studies increased.

Commonly recognized risk factors do not significantly differentiate those patients who will experience progression from those who will not (Tables 1–3).



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