Clinicopathologic assessment of twenty-six cases of rhabdomyosarcoma

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IN 1854, according to Stout,1 Weber reported a case of rhabdomyosarcoma in the tongue of a young man. In 1946, Stout1 reviewed 107 previously reported cases, added 17 new ones, and clarified the characteristics of the neoplasm for the first time. In 1950, Stobbe and Dargeon2 reported 15 cases, classifying the neoplasms as embryonal rhabdomyosarcomas. In 1956, Riopelle and Theriault3 reported six cases of a peculiar, but distinctive, form that they called alveolar rhabdomyosarcoma. In 1958, Horn and Enterline4 reported 39 cases, and classified these tumors into four categories: embryonal, alveolar, pleomorphic, and botryoid.

Rhabdomyosarcoma was believed to be a rarity, but in the last decade it has been reported to occur in almost every part of the body: extremities,1, 4–9 trunk,1, 4, 5, 7, 8 abdomen,1, 4, 5, 7, 8 lung,10 soft tissues of the head and neck,1, 4, 5, 7, 8, 11, 12 orbit,13–15 major salivary glands,16 soft palate,17 middle ear and mastoid,18 bladder,19–21 testis,22 ovary,23 and the common bile duct.4 It was also reported to occur in every age group from birth4 to the age of 90 years.19 Prognosis and methods of treatment were discussed recently by Burgert and Mills24 and by Martin, Butler, and Albores-Saavedra.25

We have studied 26 cases at the Cleveland Clinic, and the series is the basis of this report. Cases of sarcoma botryoides of the female genital tract and of other sites have not been included, because we believe that those tumors should be called mixed mesodermal tumors.

Methods and Material

During . . .



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