The Effect of Local Gastric Heating on Acid Secretion in the Dog

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MANY forms of treatment have been directed toward the stomach in an attempt to alter its acid secretion. Of the nonoperative technics, irradiation and hypothermia have become popular, each giving various degrees of success. Because of the similar effects of irradiation and of heat on animal tissues,1,2 an experimental study was undertaken early in 1963 to evaluate the histologic and secretory changes secondary to local heating of the gastric mucosa. A report of the study follows.

Material and Method

Twelve mongrel dogs whose weights ranged from 14 to 22 kg. were studied. Local gastric heating was achieved by circulating hot water through a stomach-shaped latex balloon that was inserted orally under light Nembutal anesthesia and was inflated to volumes of from 600 to 800 ml. A recirculating pump and water bath maintained a constant volume and temperature. The test group was heated at 50 C. (122 F.). Heating was maintained for an arbitrary period of 45 minutes in each animal.

In order to determine the maximum heating temperature that a dog could tolerate for the 45-minute test period, each of six dogs was subjected to gastric heating at 45, 48, 50, 52, 53, and 55 C. (113, 118.4, 122, 125.6, 127.4, and 131 F., respectively). Laparotomy was performed simultaneously so that gastric biopsy specimens could be obtained and the temperature of the mucosa and adjacent organs recorded.

The test group comprised six dogs each of which underwent gastrostomy before the gastric heating. A tube was placed in the dependent portion. . .



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