Subcutaneous Fat Necrosis with Calcifications and Hypercalcemia in an Infant

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MANY investigators have reported cases of subcutaneous fat necrosis, some with accompanying calcifications radiologically or histologically proved; few of the patients have also had elevated serum calcium levels. The purpose of this paper is to report the case of an infant with the three abnormalities, and to review the previously published cases of a similar nature.

Report of a Case

A 30-day-old white female was first admitted to the Cleveland Clinic Hospital in July, 1963, because of irritability on handling, inability to gain weight, and lumps under the skin. The infant was said to be the product of a normal pregnancy in a 38-year-old gravida 11, para 9 mother weighing 220 pounds. The labor was four hours in duration. The delivery was described as difficult, and resuscitation of the infant was necessary. The referring physician related that petechial hemorrhages were apparent on the head, and “hardened, reddened areas existed on the skin especially around the shoulder.”

A roentgenogram of the chest the first day of life was said to have shown an enlarged heart. A course of digitalis was administered for five days, and another roentgenogram was made; it was said to demonstrate a normal heart size. The infant was discharged from the hospital on the ninth postpartum day. While at home, she occasionally vomited, reported as occasionally projectile in character. The mother stated there was no history of excessive vitamin D or calcium intake by herself or by her infant. The increasing prominence of the skin lesions, failure. . .



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