An Extra Abnormal Chromosome in a Child With Mongolism and Acute Myeloblastic Leukemia

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THE purpose of this paper is to report the case of a child who had mongolism and acute myeloblastic leukemia, in whom chromosomal analyses demonstrated two populations of cells. One of these populations showed the typical trisomy of chromosome 21 with the 47 chromosomal count of mongolism. The second population was of cells with trisomy-21 plus an extra medium-sized metacentric chromosome in group C (6–12). We were consistently able to find the cells with 48 chromosomes more easily in 24-hour cultures than in the usual 72-hour cultures.

Report of a Case

A 16-month-old Negro girl was admitted to the Cleveland Clinic Hospital on November 27, 1962, because of acute leukemia. She was the thirteenth living child in the family. The father was 42 years old and the mother 39 years old at the time of the child’s admission to this hospital. All of the siblings were said to be in good health.

The child was said to be the product of a normal pregnancy and a normal delivery and was reported to have had a birth weight of 6½ pounds. She breathed poorly and sucked poorly in the immediately neonatal period, and considerable mucus was present in the pharynx. At six weeks of age jaundice was present and she was given a blood transfusion at her local hospital. The cause of this jaundice is not known.

The child was well, aside from slowness in her developmental progress, until November 15, 1962, when pallor was noted. She was admitted to the . . .



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