Benign Stricture of the Intestine Due to Irradiation of Carcinoma of the Cervix Uterl:

Author and Disclosure Information


Four hundred and twenty-two patients with carcinoma of the cervix have received irradiation at the Cleveland Clinic. This total number includes six cases (1.4 per cent) of benign stricture of the intestine which might easily have been confused with metastatic carcinoma. Subsequent to the irradiation no evidence of carcinoma was found, and, judging by present standards, none of these patients received excessive irradiation. It seems probable that the incidence of this lesion is found to be greater elsewhere as well as in this institution than the literature would indicate.

The present study directs attention to this benign lesion as a clinical entity, and offers suggestions for its prevention. It appears logical that this complication may be prevented without altering the principles of the well-proved, present efficacious radiation therapy of cervical cancer. Although there are many reports in the literature which deal with the manifestations of acute injury of the intestine following irradiation, no reports were found wherein the patients recovered from the acute symptoms and at a later time symptoms developed which were referable to benign stricture of the intestine. This condition may represent a later stage of the inflammatory process than has hitherto been observed. Of the six cases reported, five of the benign strictures occurred in the sigmoid colon and one in a loop of the lower part of the small intestine.

A patient who complains of unusual abdominal symptoms, particularly if they simulate those of intestinal obstruction, several months or even years following radiation therapy, may have. . .



Next Article: