The Treatment of Diabetes Insipidus with Benzydroflumethiazide* and Potassium Chloride in Eleven Patients
JOHN F. LEFEBVRE, M.D.
Department of Pediatrics
O. PETER SCHUMACHER, M.D., Ph.D.
Department of Endocrinology and Metabolism
REPORTS1–5 of experimental treatment of diabetes insipidus with chlorothiazide and hydrochlorothiazide, and the more recent report2 of the similar treatment of patients, prompted us to treat two patients, with this disease, with benzydroflumethiazide, a chlorothiazide-like drug.* Because hypokalemia was a problem reported by other investigators,3,4 we used benzydroflumethiazide supplemented with potassium chloride. It was not our intention to make a detailed laboratory study to assess the results of treatment, but merely to assess its clinical effectiveness by means of pertinent simple laboratory tests that can be done on an outpatient basis.
The effects of the drug were ascertained in 11 patients with diabetes insipidus. In six of them there were definite favorable responses to the therapy. The 24-hour urinary volumes decreased from original values in the range of 4,000 to 10,000 ml. to between 2000 and 5000 ml. In two patients the urinary volumes decreased to approximately half the original values for a few days, and then increased again. In two other patients there were no responses at any time to the therapy. The results in the 11 patients are summarized in Table 1.
Illustrative Case Reports
Case 1. A 12-year-old white girl‡ was examined on August 20, I960, because of symptoms of polydipsia and polyuria of 10 months’ duration. Her birth, developmental, and family history were noncontributory. Her height was 60 inches and she weighed 109 pounds; blood pressure was 114/74 mm. of Hg; pulse rate, 84; the remainder of the physical examination disclosed no abnormality. The blood . . .