Article

Effects of Desoxycorticosterone and Salt on an Experimental Nephrotic Syndrome Due to Ligation of a Renal Vein

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Abstract

A nephrotic syndrome has been elicited in a small proportion of rats that underwent subtotal ligation of the renal vein and contralateral nephrectomy.1 A similar state has also been observed in rabbits, in which it was regularly intensified by an excess of salt given in the drinking water.2,3 Our studies show that this effect of salt is likewise demonstrable in rats, and that by giving desoxycorticosterone acetate with salt to intensify further the effect, the pattern of renal injury is only complicated by a superimposed nephrosclerosis.

Methods

The effects of salt were studied in three groups of rats. Group I, used as control, comprised 10 uninephrectomized animals; group II and group III comprised respectively 19 and 21 rats that underwent unilateral renal venous constriction and 12 days later contralateral nephrectomy. Drinking fluid consisted of 1 per cent sodium chloride solution, in groups I and II; in group III, tap water was first given starting at the time of renal venous constriction, followed by 1 per cent saline solution on the twenty-fifth day, and 1.25 per cent saline solution on the thirty-eighth day. The experiment was terminated on the fifty-second day.

The effects of desoxycorticosterone acetate (hereinafter termed DCA) were studied in four groups of 10 animals each at the daily dose levels of 1 mg. of DCA (groups I and II) and of 0.2 mg. of DCA (groups I II and IV); injections of DCA in aqueous suspension were given subcutaneously. Animals of groups I and III were uninephrectomized on . . .


 

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