Angiography of the Coronary Arteries in Dogs

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TWO previous articles have reported our experience with angiography of the coronary arteries in living dogs: the first1 described the technic in dogs with normal coronary arteries and the second2 showed that surgically produced defects in the coronary arteries could be recognized. This paper describes an extension of the work. Angiography was performed on the animals on the operating table while the circulation was being maintained by a pump-oxygenator and reparative work on the coronary arteries was done. There were three specific aims: (1) to obtain satisfactory diagnostic angiograms of the coronary arteries at the time of operation (which will be mandatory before surgical repair of the coronary arteries of patients can be attempted); (2) to find a contrast medium that might safely be mixed with potassium salts used to produce elective cardiac arrest; and (3) to evaluate roentgenographically the anastomotic or reparative procedure before the chest was closed.

Material and Method

Ten mongrel dogs were used, weighing from 15 to 25 kg. The animals were given morphine sulfate as a preanesthetic and were anesthetized with either thiopental sodium (Pentothal sodium, Abbott) or pentobarbital sodium (Nembutal sodium, Abbott). Procaine hydrochloride (Novocain, Winthrop) was used locally for skin anesthesia and for intercostal block. The heart-lung machine was connected in the usual manner.3 The blood was drawn into the machine from the venae cavae through cannulae inserted through the jugular and femoral veins and returned through cannulae in both femoral arteries. A roentgen tube was mounted over the table at a target . . .



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