Angiography of the Coronary Arteries in the Live Dog

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AN earlier article1 reported our experience with coronary angiography in normal dogs. The present report describes observations on the angiographic diagnosis of experimentally induced abnormalities of the coronary arteries in dogs.


The procedure used was described in the previous article1 and need not be reported in detail. Mongrel dogs were used, weighing approximately 10 kg. each. Angiograms were made under morphine-pentobarbital (Nembutal sodium, Abbott) anesthesia. A 50-cm. cardiac catheter was passed into the root of the aorta through a carotid artery if available, but brachial and femoral arteries were employed with equal success. We depended on our sense of touch and fluoroscopy to place the catheter tip near the coronary ostia.

Injections of radiopaque medium were made either rapidly or slowly. Ninety per cent Hypaque sodium (sodium diacetrizoate, Winthrop) was used as the contrast medium in seven, and 70 per cent Diodrast (iodopyracet, Winthrop) in six experiments. The contrast medium usually was injected in 10-cc. amounts at intervals of a few minutes. The average total dose of Hypaque sodium was 43 cc. per dog, or approximately 4 cc. per kilogram of body weight; one dog received 86 cc. within one hour's time. The average total dose of Diodrast was 55 cc. per dog, or about 5.5 cc. per kilogram; one dog received 80 cc. within one hour's time.

Eleven dogs survived the coronary artery defects that had been produced days or months before in the following ways: (1) ligation of major coronary artery, three dogs; (2) ligation of branches. . .



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