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Ocular Manifestations of Sarcoidosis

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Abstract

OCULAR lesions occur in approximately 50 per cent of patients having sarcoidosis. It is the purpose of this paper to review these manifestations, to discuss their possible diagnostic significance and their treatment, and to summarize the findings in 11 patients.

Sarcoidosis is a ubiquitous disease of unknown etiology. Although it has received much attention in the literature of the past 50 years, no specific therapeutic agent has yet been found. In 1948 the Committee on Sarcoidosis of the National Research Council of the United States1 defined sarcoidosis as:

. . . a disease of unknown etiology. Pathologically it is characterized by the presence in any organ or tissue of epithelioid cell tubercles with inconspicuous or no necrosis and by the frequent presence of refractile or apparently calcified bodies in the giant cells of the tubercles. The lesions may be replaced by fibrosis, hyalinization or both. Clinically, the lesions may be widely disseminated. The tissues most frequently involved are the lymph nodes, lungs, skin, eyes, and bones (particularly of the extremities). The clinical course usually is chronic with minimal or no constitutional symptoms. However, there may be acute phases characterized by malaise or fever. There may be signs or symptoms referable to the tissues and organs involved. The intracutaneous tuberculin test is frequently negative. The plasma globulins are often increased. The outcome may be clinical recovery without radiographically visible residue or there may be impairment of the organs involved, or a continued chronic course of the disease.

Sarcoidosis affects young adults. . .


 

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