Nisentil Hydrochloride Analgesia and Pentothal Sodium Amnesia in Dental Surgery

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FEAR of even the simplest dental extraction under local anesthesia induces in many patients a state of anxiety which must be controlled to render them calm, relaxed, and co-operative for the surgical procedure. We recently initiated a clinical study of analgesia and amnesia for dental extractions in ambulatory patients in whom analgesia was produced by Nisentil hydrochloride (alpha-prodine hydrochloride, Hoffmann-LaRoche) and amnesia by Pentothal sodium (thiopental sodium, Abbott). Nisentil hydrochloride has been used widely in obstetrics,1 urologic examinations,2,3,4 endoscopic procedures,5 and oral surgery.4,6

This preliminary report presents our experience with Nisentil hydrochloride and Pentothal sodium in 128 cases requiring dental surgery.

An ideal analgesic for dental extraction (1) permits rapid induction, (2) effectively relieves pain, (3) does not interfere with the patient’s ability to cooperate during the procedure, (4) has a total action not significantly longer than the operating time, and (5) causes a minimum of side reactions. Nisentil hydrochloride appeared to have most of these characteristics and it was chosen for our clinical studies in dental surgical procedures.

Alphaprodine hydrochloride. The use of alphaprodine hydrochloride was first reported by Ziering and Lee, in 1947.7 Its chemical structure is similiar to that of meperidine (Demerol hydrochloride) — a synthetic piperidine derivative — but not to that of morphine. In a comparative study of Nisentil hydrochloride and morphine, in which equally potent analgesic doses of the two agents were given to normal volunteers, Gross, Holland, and Schueler8 found that Nisentil hydrochloride had a more rapid onset of action, a shorter period of effectiveness,. . .



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