LAWRENCE J. McCORMACK, M.D.
Department of Pathology
WILLARD PARKER, M.D.
Department of Otolaryngology
MALIGNANT SYNOVIOMA is a well-recognized clinical entity as evidenced by there view of 222 cases by Tillotson, McDonald, and Janes1 in 1951, and by other series subsequently reported. We are presenting two noteworthy cases: one in which the biologic behavior of the tumor was remarkable and the patient survived an exceptionally long time; the other in which the tumor arose in the anterior portion of the neck, a region not previously reported as a site of malignant synovioma.
Case 1. A 32-year-old white woman was admitted to the Cleveland Clinic Hospital on March 23, 1925, because of pain, swelling, and local discoloration behind the left knee. The symptoms had been present for 15 years, but during the few months before admission had gradually increased in severity.
Physical examination revealed a firm ovoid tumor mass in the popliteal space, which apparently was attached to underlying tissues but not to skin. The overlying skin showed slight bluish discoloration. There was no roentgen evidence of bony change or soft-tissue calcification. The tumor was removed on April 20, 1925, 28 days after admission.
The surgical specimen was a lobulated, soft, pale-gray, poorly encapsulated mass, 12 by 7 by 6 cm.; on bisection the cut surface was grayish white, homogeneous, friable, and moderately vascular. A review of the sections revealed the cell architecture to be typically that of malignant synovioma but with a pronounced epithelial appearance of the cells forming lumina (Fig. 1A). The irregularly shaped spaces were numerous and lined by prominent,. . .