Hyperthyroidism Showing Carbohydrate Metabolism Disturbances


For several decades writers in this country and abroad have reported the coincident finding of glycosuria in some cases of hyperthyroidism. Joslin and Lahey,1 in their recent study of 500 cases of disease of the thyroid, reported the occurrence of glycosuria in 38.6 per cent of 228 cases of primary hyperthyroidism and in 27.7 per cent of 83 cases of adenomatous goiter with secondary hyperthyroidism, as compared with only 14.8 per cent in 189 cases of nontoxic goiter and 13.6 per cent of patients without diabetes or any disease of the thyroid gland. In a series of 100 dextrose tolerance tests which I2 did in 82 cases of hyperthyroidism and 10 cases of colloid goiter, there was a fasting glycosuria in 19 per cent. In table I are given the reports of various authors as to the incidence of glycosuria in cases of hyperthyroidism.

When chemical analyses of the blood began to be generally used, hyperglycemia, either with or without glycosuria, was demonstrated in sporadic cases of hyperthyroidism. A review of the literature showing the incidence of hyperglycemia in hyperthyroidism (table 2) shows a great discrepancy in the findings of different investigators.

Experimental studies on animals made to determine the relation of the thyroid gland to the blood sugar content showed that extirpation of the thyroid gland leads to a lower blood sugar level, while, on the other hand, the injection of thyroxin, the feeding of hashed thyroid gland to animals or the injection of thyroid extract produces hyperglycemia. In. . .



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