Lymphatic Leukemia Occurring Simultaneously In Negro Brother and Sister

Author and Disclosure Information


THIS report concerns a brother and sister, Negroes, a year apart in age, who apparently developed chronic lymphatic leukemia simultaneously. It is of special interest because: (1) we have found no report in the literature of instances of leukemia developing in members of the same family at so nearly the same time and age; (2) it is unusual for members of the same family to develop leukemia; (3) the occurrence of leukemia in the Negro race is less frequent than in the Caucasian, according to the report of Pizzolato1 who reviewed a series of cases of leukemia at Charity Hospital, New Orleans, where a high percentage of patients are Negroes.

Case Reports

Case 1. A man, aged 40, was admitted to the Cleveland Clinic on February 22, 1946, complaining of swellings about the neck which had increased in size during the previous 9 months. The swellings interfered with breathing and swallowing and caused choking sensations. The patient also had been aware of lumps in his right armpit for the past month. His previous illnesses were noncontributory.

Pertinent physical findings included large, discrete, elastic nontender masses of enlarged nodes which were palpable in each side of the neck, in each axilla and in the groins. His tonsils completely obliterated the otopharynx; the spleen was enlarged to 10 cm. below the left costal margin. Roentgenograms showed enlargement of mediastinal nodes.

Laboratory examinations were normal except for the blood findings. The red cell count was 5,100,000 with slight anisocytosis, poikilocytosis and pallor.

Nucleated. . .



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