The Use of Banthine in the Treatment of Duodenal Ulcer

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The treatment of duodenal ulcer and its complications was reviewed recently by one of us (Collins1). Eighty-five per cent of our patients obtain relief on the treatment outlined and do not require surgery. The remaining 15 per cent recently have been subjected to vagotomy and gastroenterostomy. Because of this small group demonstrating intractable ulcers, and because of the inconvenience of hourly feedings and medication (which interferes, frequently, with the patient’s livelihood), we are interested in any new preparation that serves to relieve pain, heal the ulcer, and eliminate the necessity for surgery.

Longino, Grimson et al2 reported that Banthine*, an anticholinergic drug, caused prolonged depression of gastrointestinal motility and usually reduction in volume and acidity of secretions from the stomach. Banthine may serve the purpose of a “medical vagotomy.” Such treatment for peptic ulcer is not new. Belladonna and atropine derivatives have been used for a long time as adjuncts in the treatment of peptic ulcer. Belladonna and atropine frequently cause severe side effects, however, such as dryness of the mouth and blurring of vision, which make them impractical in the reduction of gastric acidity. Grimson et al3 have reported the beneficial use of Banthine in 100 patients having duodenal ulcer. Because the drug appears to be effective in reducing gastric acidity without inducing distressing complications, we became interested in its application for duodenal ulcers which had not responded to conventional therapy.

Inasmuch as the results have been unusually satisfactory, we present this preliminary report on our experience with Banthine.



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