Hodgkin’s Disease and Pregnancy

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DOES pregnancy cause exacerbations of Hodgkin’s Disease? In 1888, when Wright1 reported the first known instance of Hodgkin’s disease complicating pregnancy, and until 1948 when Summers and Reid2 gave their account, this question has been debated and several individual cases have appeared in the literature. Perrier3 described 5 instances and Gilbert4 7 pregnancies in 5 patients. Our report concerns 4 proven cases of Hodgkin’s disease observed at the Cleveland Clinic between 1930 and 1949, and associated with known pregnancy during the course of the disease.

Case Reports

Case 1. A woman, aged 21, was first seen at the Clinic on July 24, 1930. Her chief complaint was dyspnea. Six months previously she had had pleurisy with effusion following a cold. She had undergone numerous thoracenteses but the fluid had reformed so rapidly that her dyspnea was relieved only for a day or so after aspiration.

Our examination disclosed adenopathy in the left supraclavicular and axillary lesions. The entire chest on the left side was flat to percussion and the heart displaced to the right. A roentgenogram showed complete opacification of the left side of the chest with displacement of both heart and mediastinum into the right thoracic cavity. A diagnosis of Hodgkin’s granuloma was made by biopsy of an axillary node.

Thoracentesis of about 2000 cc. daily was required (between July 24, 1930 and August 12, 1930) in order to relieve dyspnea. The fluid was a cloudy yellow and contained numerous lymphocytes. Roentgen therapy was given to the anterior and. . .



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