Tetraethylammonium Chloride in Multiple Sclerosis

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DIRECT observation of the blood vessels in the central nervous system during sympathetic stimulation or after the injection of various drugs the subject of a number of published reports. Most convincing are the observations made by Franklin and Brickner,1 who have relieved retinal vasospasm and scotomas simultaneously by the use of amyl nitrite or intravenous papaverine. They postulate that lesions of multiple sclerosis result from, or are associated with, vasospasm, that scotomas in patients with multiple sclerosis are the result of vasospastic lesions in the retina, and that such disturbances apply with equal validity to any portions of the central nervous system.

Lyons el al.2 have demonstrated that tetraethylammonium chloride is capable of relieving vasospasm in man by blocking the autonomic ganglia. If there is some truth to the assumption that the acute or the exacerbative symptoms of multiple sclerosis contain the element of vasospasm, tetraethylammonium chloride may produce a modifying influence upon these acute symptoms in perhaps the same fashion as do the injections of histamine by Horton, Wagener, Aita, and Woltman.3

Several recent articles on the treatment of multiple sclerosis have suggested that, irrespective of the underlying cause, one factor in the disease is some vascular disorder such as a venous stasis or change in vasomotor tone. Such hypotheses form the basis for the use of histamine and dicumarol.

In pursuance of this hypothesis tetraethylammonium chloride has been administered to a number of patients manifesting the acute and chronic symptoms of multiple sclerosis. All of the patients have. . .



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