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Polycythemia Vera Rubra Treated with Nitrogen Mustard

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Abstract

IT has been suggested by Jacobson et al.1 that polycythemia may be controlled by nitrogen mustard. These workers observed 5 cases, the longest remission extending over seventeen months.

The case of polycythemia vera rubra reported here was adequately managed with the methyl bis-amine form of nitrogen mustard. The results support the view of Jacobson and his colleagues.

Case Report

A man, aged 51, came to the Cleveland Clinic complaining of progressive exhaustion and nervousness. Four years previously, while working as a gasoline station attendant, he had noted impaired vision and inability to coordinate his hand movements properly. A diagnosis of polycythemia was made, and he was given 12 to 15 x-ray treatments, which apparently resulted in some improvement. On admission his blood pressure was 212 systolic, 130 diastolic. The conjunctivae were injected and the patient appeared plethoric. The spleen was palpable 2 fingers’ breadth below the left costal margin. The fundi revealed findings consistent with essential hypertension and grade II arteriosclerosis. Clubbing of the fingers was not noted. The urinalysis, blood sugar and urea, and Wassermann and Kahn reactions were normal. The urea clearance was 60 per cent the first hour and 62 per cent the second hour. Roentgenologic examination of the chest and an electrocardiogram did not reveal any abnormal findings. The complete blood count was 8,640,000 red cells; hematocrit reading 76 cc., or 169 per cent of normal; volume index 0.98; hemoglobin 162 per cent; white blood count 13,500; neutrophils 79 per cent; lymphocytes 13 per cent; eosinophils. . .


 

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