Bone Marrow Studies in Hodgkin’s Disease
OSSEOUS involvement in Hodgkin’s disease has been reported in numerous papers, with a varying percentage of cases showing typical bone lesions either by roentgenologic study or by microscopic examination of the pathologic tissue. In 172 cases studied, Craver and Copeland1 found bone involvement in 15.7 per cent. Goldman2 reported roentgenologic evidence of disturbances of the osseous system in 6.6 per cent of 212 cases. Lymphogranulomatous foci of the bone marrow were found in 11 of 14 cases of Hodgkin’s disease examined by Steiner,3 and in 7 of the 11 cases examined the sternal marrow was involved. It has been shown repeatedly that the bones containing active hematopoietic tissue, such as the vertebrae, sternum, pelvis, skull, and ribs, are most often affected.
Morrison and Samwick4 reported bone marrow aspirations to be a diagnostic aid in 8 cases of Hodgkin’s disease in which clinical signs and symptoms and routine blood examinations failed to be of assistance. They noted that the red cell mechanism showed slightly increased activity but that, on the other hand, there was an increase in reticulum cells and a moderate eosinophilia and increase in megakaryocytes. Varadi5 was able to make the diagnosis of Hodgkin’s disease by sternal puncture in 1 case. The aspirated material contained a mixture of blood, fat droplets, lymphocytes, and large cells with enormous nuclei, containing nucleoli, which were considered to be Sternberg cells. In the same case Sternberg cells were found on puncture of a lymph gland and also on histologic examination. X-ray examination of. . .