Brucella Abortus Infection of the Gall-Bladder Treated with Streptomycin

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Although streptomycin inhibits the growth of Brucella organisms in vitro, its use in the treatment of brucellosis in man has given conflicting and, for the most part, disappointing results.1,2,3,4,5,6,7,8 The antibiotic agent is known to be excreted in the bile in considerable amounts, and it was this fact which suggested that it might be more effective in the treatment of Brucella infections of the gallbladder than in similar infections in other tissues. In the case to be reported here, Brucella abortus was cultured from bile obtained by duodenal drainage, and treatment with streptomycin* resulted not only in control of the patient's symptoms but also in persistently negative subsequent cultures of the bile.

Case Report

A white, single man, an office worker, aged 58, was admitted to the hospital on July 18, 1946, because of lassitude, weakness, and fatigue of two months' duration. His appetite had been poor, and he had lost 8 pounds in weight. There had been no known fever, chills, or night-sweats. The past medical history was negative except for an influenza-like infection five years earlier. The patient denied having had contact with farm animals and the use of unpasteurized dairy products.

Physical examination disclosed a well-developed and well-nourished man who did not appear acutely ill but seemed moderately depressed. The temperature on admission was 100 F., the pulse 84, and the blood pressure 120 systolic and 84 diastolic. The pupils reacted normally, and ophthalmoscopic examination showed no diagnostic changes. The lungs and heart were normal on percussion. . .



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