Nitrogen Mustard Therapy

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Following World War I the therapeutic value of nitrogen mustard (HN2) was investigated by numerous workers both in this country and in Europe. In the United States Krumbhaar,1 Pappenheimer and Vance,2 and Warthin and Weller3 presented their observations on its action in certain neoplastic diseases in mice and rats. The medical profession took no advantage of the results of this research until its value was suggested by the Allied catastrophe at Bari during the invasion of Italy in 1943.4 At this time the actions of the mustard gases were thoroughly studied and their potentialities realized.

Shortly after this incident the first report on the clinical use of nitrogen mustard was made by Gilman,5 Goodman, et al.,6 who presented a series of terminal cases in which tris-amine hydrochloride had been used. In 1946 there appeared several reports6,7 of the value of nitrogen mustard in the management of certain types of neoplastic diseases. These articles present an excellent evaluation of the present status of nitrogen mustard therapy, and the reader is referred to them for a thorough understanding of the actions of the halogenated alkyl amines.

In this article we will present our experience with the methyl bisamine hydrochloride and the results thus far noted.

With two or three exceptions, all of our patients were ambulatory, remaining at bedrest for only thirty minutes following each injection. No ill effects were noted.

The nitrogen mustard was prepared in 10 cc. of sterile normal saline solution, 0.9 per cent, and in all but 1. . .



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