Intra-Arterial Transfusion in the Treatment of Experimental Hemorrhagic Shock
OTTO GLASSER, Ph.D.
IRVINE H. PAGE, M.D.
Experiments on the value of intra-arterial transfusion in the treatment of hemorrhagic shock were extended to an evaluation of the same method in extreme emergencies, including resuscitation. In a previous paper1 we described the production of severe hemorrhagic shock in dogs and subsequent intra-arterial blood transfusion of the shocked animals. As a result of these experiments three criteria for prediction of the probable fate of the animals in shock were established: (1) persistently falling arterial pressure during the hypotensive period indicates small chance for survival; (2) the larger the intake of blood during arterial transfusion to establish normal pressure, the smaller the chance of survival; (3) the more nearly normal the pressor response to adrenalin after transfusion the better the chance of survival.
The experimental technic for production of shock was described in the previous report. Suffice it to repeat here that the animal is bled rapidly from a femoral artery (fig. 1, A) until an arterial pressure of 50 mm. Hg is established. A canula (A) is connected through one branch with a mercury manometer (B) which permits recording the arterial pressure on a kymograph. The other branch leads to a bottle-reservoir (C) in which the withdrawn blood is stored under controlled pressure (hand pump, D; manometer, E; and sphygmomanometer, F). The 50 mm. Hg level of hypotension is maintained for ninety minutes, after which it is lowered to 30 mm. Hg by further withdrawal of blood. This 30 mm. Hg level is held for forty-five more minutes,. . .