From 1934 to 1943 seventy-seven cases of thromboangiitis obliterans were diagnosed at the Cleveland Clinic. Only two of these cases occurred in women, and these were observed during the past two years. It is common knowledge that this condition is exceedingly rare in the female; the cause for this has never been determined.
The two cases discussed in this paper bring the total number of cases on record to thirty-one. In a review of the literature in 1938, Millman1 found only twenty-two authenticated cases, to which he added the report of one case. Since that time the following cases have been reported: Atlas2 described the condition in a woman 68 years old; Seidenstein3 reported a case in a 33 year old woman, which was indistinguishable from the typical syndrome in a man; Robinson4 reported a case associated with the menopausal syndrome; Wilensky and Collens5 reported two cases occurring in sisters; Hammarström6 discussed the occurrence of the syndrome with gangrene of the extremities and of a loop of small intestine with portal thrombosis.
Case 1—A Gentile woman, aged 32, was admitted to the Cleveland Clinic on May 5, 1942 because of ulceration of the toes and fingers. Three months prior to her admission she first noticed pain and slight swelling with some coldness and increased sensitivity in both of her feet. The pain was rather severe and came on suddenly but persisted even when she was at rest. On several occasions the calf area was quite tender, and several small,. . .