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Trends in LDL-C and 2013 Treatment Guidelines

Clin Cardiol; ePub 2018 Nov 15; Superko, et al

In a large cohort of patients between 2012 and 2017, declining blood low-density cholesterol (LDL-C) levels indicated no additional reduction since the publication of the 2013 /American College of Cardiology/American Heart Association (ACC/AHA) guidelines. Researchers examined data from 507,752 patients nationally aged ≥16 years whose fasting bloods were sent to Boston Heart Diagnostics for direct LDL-C measurements. Between 2012 and 2017, age-adjusted concentrations were examined by analysis of covariance and LDL-C ≥160 mg/dL by logistic regression. Among the findings:

  • Age-adjusted mean LDL-C concentrations increased significantly in men and women.
  • The percentage with LDL-C ≥160 mg/dL also increased significantly in both men and women.
  • Similar results were found in those aged 40‒75 years.


Superko HR, Williams PT, Dansinger, Schaefer E. Trends in LDL-cholesterol blood values between 2012 and 2017 suggest sluggish adoption of the recent 2013 treatment guidelines. [Published online ahead of print November 15, 2018]. Clin Cardiol. doi:10.1002/clc.23115.