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Plasma LDL-C and Heart Function in Patients with T2D

There is an inverse correlation between plasma low-density lipoprotein cholesterol (LDL-C) and heart function in individuals with type 2 diabetes (T2D), a new study found. The cross-sectional study included 118 patients aged >21 years with T2D who received antidiabetic and cholesterol-lowering medications. Participants received blood sampling for plasma lipids after a 12-hour fast, followed by transthoracic echocardiology in the cardiology clinic. Researchers found:

  • Study participants were divided into 2 groups according to their plasma LDL-C levels.
  • Those with lower plasma LDL-C levels had better heart function, as measured by the left ventricular ejection fraction (LVEF), compare with patients with higher LDL-C levels.
  • Multivariate regression analysis also showed an inverse correlation between plasma LDL-C and LVEF.


Cheng PC, Hsu SR, Li JC, et al. Plasma low-density lipoprotein cholesterol correlates with heart function in individuals with type 2 diabetes mellitus: A cross-sectional study. [Published online ahead of print April 11, 2019]. Front Endocrinol. doi:10.3389/fendo.2019.00234.