Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

PCSK9 Inhibitors for Tx of Hypercholesterolemia

Ann Pharmacother; ePub 2018 Apr 1; Patel, et al

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor therapy is an effective low-density lipoprotein cholesterol (LDL-C) lowering option for patients with the highest risk of cardiovascular disease (CVD) events and high LDL-C despite the use of statin therapy, according to a recent review. Clinical trials include were from January 2012 to March 2018. Researchers found:

  • All trials evaluating evolocumab and alirocumab demonstrated significant LDL-C lowering vs comparators.
  • 2 trials revealed a decrease in the major adverse cardiovascular events (MACE) end point with PCSK9 inhibitor use.
  • No significant safety concerns apart from injection site reactions were noted.


Patel RS, Scopelliti EM, Olugbile O. The role of PCSK9 inhibitors in the treatment of hypercholesterolemia. [Published online ahead of print April 1, 2018]. Ann Pharmacother. doi:10.1177/1060028018771670.