Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

PCSK9 Inhibitors for Tx of Hypercholesterolemia

Ann Pharmacother; ePub 2018 Apr 1; Patel, et al

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor therapy is an effective low-density lipoprotein cholesterol (LDL-C) lowering option for patients with the highest risk of cardiovascular disease (CVD) events and high LDL-C despite the use of statin therapy, according to a recent review. Clinical trials include were from January 2012 to March 2018. Researchers found:

  • All trials evaluating evolocumab and alirocumab demonstrated significant LDL-C lowering vs comparators.
  • 2 trials revealed a decrease in the major adverse cardiovascular events (MACE) end point with PCSK9 inhibitor use.
  • No significant safety concerns apart from injection site reactions were noted.


Patel RS, Scopelliti EM, Olugbile O. The role of PCSK9 inhibitors in the treatment of hypercholesterolemia. [Published online ahead of print April 1, 2018]. Ann Pharmacother. doi:10.1177/1060028018771670.

This Week's Must Reads

Stroke endovascular therapy: The more you do, the better you do, Sheth SA et al. ISC 2019, Abstract 002

PAD tied to higher prevalence of LV diastolic dysfunction, Yanaka K et al. J Cardiol. 2019 Feb 18. doi: 10.1016/j.jjcc.2019.01.011

Diabetic kidney disease, retinopathy associated with PAD in patients with foot ulcers, Megallaa MH et al. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1287-92.

LDL-C & CV Outcomes in Hypertensive Patients, Intl J Cardiol; ePub 2019 Jan 15; Nguyen, et al

Must Reads in Hypercholesterolemia

LDL-C & CV Outcomes in Hypertensive Patients, Intl J Cardiol; ePub 2019 Jan 15; Nguyen, et al

High Rates of PCSK9 Inhibitor Access & Initiation, J Clin Lipidol; ePub 2019 Jan 14; Reynolds, et al

LDL-C Levels and the Risk of Sepsis, JAMA Netw Open; ePub 2019 Jan 18; Feng, et al

Statins for CV Prevention in Elderly Patients, Am J Med; ePub 2019 Jan 18; Bezin, et al

Hypercholesterolemia & Statin Exposure in Cirrhosis, Gastroenterology; ePub 2019 Jan 18; Kaplan, et al