Clinical Edge

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Holiday Season and Risk of Hypercholesterolemia

Atherosclerosis; ePub 2018 Dec 19; Vedel-Krogh, et al

Celebrating Christmas and the holiday season is associated with higher levels of total and low-density lipoprotein cholesterol (LDL-C) and a higher risk of hypercholesterolemia in individuals in the general population. This according to an observational study of 25,764 individuals from the Copenhagen General Population Study aged 20‒100 years. The main outcome measures were mean total and LDL-C levels. Hypercholesterolemia was defined as total cholesterol >5 mmol/L (>193 mg/dL) or LDL-C >3 mmol/L (>116 mg/dL). Researchers found:

  • Mean levels of total and LDL-C cholesterol increased in individuals examined in summer through December and January.
  • Compared to individuals examined in May-June, those examined in December-January had 15% higher total cholesterol levels; the corresponding value of LDL-C was 20%.
  • 77% of those attending the study during the first week of January had LDL-C >3mmol/L (116 mg/dL) and 89% had total cholesterol >5 mmol/L (193 mg/dL).
  • The multivariable adjusted odds ratio of hypercholesterolemia was 6.0 compared with individuals attending the study during the rest of the year.


Vedel-Krogh S, Kobylecki CJ, Nordestgaard BG, Langsted A. The Christmas holidays are immediately followed by a period of hypercholesterolemia. [Published online ahead of print December 19, 2018]. Atherosclerosis. doi:10.1016/j.atherosclerosis.2018.12.011.

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Stroke endovascular therapy: The more you do, the better you do, Sheth SA et al. ISC 2019, Abstract 002

PAD tied to higher prevalence of LV diastolic dysfunction, Yanaka K et al. J Cardiol. 2019 Feb 18. doi: 10.1016/j.jjcc.2019.01.011

Diabetic kidney disease, retinopathy associated with PAD in patients with foot ulcers, Megallaa MH et al. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1287-92.

LDL-C & CV Outcomes in Hypertensive Patients, Intl J Cardiol; ePub 2019 Jan 15; Nguyen, et al

Must Reads in Hypercholesterolemia

LDL-C & CV Outcomes in Hypertensive Patients, Intl J Cardiol; ePub 2019 Jan 15; Nguyen, et al

High Rates of PCSK9 Inhibitor Access & Initiation, J Clin Lipidol; ePub 2019 Jan 14; Reynolds, et al

LDL-C Levels and the Risk of Sepsis, JAMA Netw Open; ePub 2019 Jan 18; Feng, et al

Statins for CV Prevention in Elderly Patients, Am J Med; ePub 2019 Jan 18; Bezin, et al

Hypercholesterolemia & Statin Exposure in Cirrhosis, Gastroenterology; ePub 2019 Jan 18; Kaplan, et al