Among asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease (CVD), elevated lipoprotein(a) (Lp[a]) levels are associated with higher coronary artery calcium (CAC) scores, a recent study found. Researchers evaluated the association between Lp(a) levels and coronary atherosclerotic burden in 432 individuals with premature ASCVD and in 937 healthy asymptomatic family members. CAC scores were only measured in asymptomatic family members. They found:
- 16% of participants had elevated Lp(a) levels of ≥50 mg/dL.
- Individuals with Lp(a) >50 mg/dL have a higher prevalence of CV events.
- In asymptomatic individuals, Lp(a) >50 md/dL is associated with higher CAC scores of ≥100 as well as with age- and gender-corrected CAC scores ≥80th percentile.
Verweij SL, de Ronde MWJ, Verbeek R, et al. Elevated lipoprotein(a) levels are associated with coronary artery calcium scores in asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease. [Published online ahead of print February 17, 2018]. J Clin Lipidol. doi:10.1016/j.jacl.2018.02.007.