Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Dual Lipid-Lowering Therapy Better?

Atherosclerosis; 2018 Feb; Gragnano, et al

Dual-lipid-lowering therapy (DULT) is more effective than statin monotherapy in high-risk patients with coronary artery disease (CAD), according to a recent review. The review determined that in recent trials, combination strategies involving a statin and non-statin agent have been shown to promote coronary atherosclerosis regression and improve cardiovascular (CV) outcomes in patients with moderate-to-high CV risk. The authors concluded:

  • DULT should be implemented in patients above the recommended low-density lipoprotein cholesterol (LDL-C) target on a high-intensity statin and might be proposed as a first-line strategy in certain patients regardless of their LDL-C levels.
  • Preference for 1 of the 2 strategies (NPC1L1 blockade or PCSK9 inhibition) should be evaluated case by case, according to the patient’s characteristics, LDL-C levels, risk profile, and national regulatory agency indications.


Gragnano F, Calabró P. Role of dual lipid-lowering therapy in coronary atherosclerosis regression: Evidence from recent studies. Atherosclerosis. 2018;269:219-228. doi:10.1016/j.atherosclerosis.2018.01.012.

This Week's Must Reads

Anticoagulation in Patients with AF and HF, Clin Cardiol; ePub 2018 Dec 23; Contreras, et al

Serum Uric Acid, Silent MI & Mortality, Am J Cardiol; ePub 2018 Dec 19; Ahmad, et al

Catheter Ablation for AF in Adults with CHD, Heart Rhythm; ePub 2018 Dec 26; Liang, et al

Cognitive Impairment in Adults with Incident HF, J Card Fail; ePub 2018 Dec 22; Sterling, et al

LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

Must Reads in Hypercholesterolemia

LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

Hypertriglyceridemia in Statin-Treated Adults, J Clin Lipidol; ePub 2018 Dec 1; Fan, et al

AHA Statement: Statin Safety & Adverse Events, Arterioscler Thromb Vasc Biol; ePub 2018 Dec 10; Newman, et al

LDL-C Reduction & Arterial Wall Inflammation, Eur Heart J; ePub 2018 Dec 18; Stiekema, et al

Holiday Season and Risk of Hypercholesterolemia, Atherosclerosis; ePub 2018 Dec 19; Vedel-Krogh, et al