Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Elevated Lp(a) & FH Increase CAD Risk?

Clin Cardiol; ePub 2018 Feb 26; Ellis, Pang, et al

In patients admitted to the coronary care unit (CCU), the combination of elevated lipoprotein(a) (Lp[a]) and familial hypercholesterolemia (FH) is associated with increased coronary artery disease (CAD) risk, a recent study found. Plasma Lp(a) concentrations were measured in consecutive patients admitted to the CCU with an acute coronary syndrome (ACS) or prior history of CAD for 6.5 months. Premature CAD was diagnosed in those aged <60 years, with the relationship between this and elevated Lp(a) and FH determined by logistic regression. Among the details:

  • 316 patients were screened; 163 (51.6%) had premature CAD.
  • Elevated Lp(a) and FH were identified in 27.0% and 11.6% of patients, respectively.
  • Both disorders were identified in 4.4% of individuals.
  • Elevated Lp(a) and FH phenotype were more common with premature vs nonpremature CAD.


Ellis KL, Pang J, Chieng D, et al. Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis. [Published online ahead of print February 26, 2018]. Clin Cardiol. doi:10.1002/clc.22880.

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LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

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AHA Statement: Statin Safety & Adverse Events, Arterioscler Thromb Vasc Biol; ePub 2018 Dec 10; Newman, et al

LDL-C Reduction & Arterial Wall Inflammation, Eur Heart J; ePub 2018 Dec 18; Stiekema, et al

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