Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Clinical Pharmadynamics of Evolocumab

Clin Pharmacokinet; ePub 2018 Jan 20; Kasichayanula, et al

The pharmacodynamic effects of PCSK9 inhibitor evolocumab are rapid, with maximum suppression within 4 hours, according to a recent review of the clinical pharmacokinetics and pharmacodynamics. The review also found:

  • Evolocumab exhibits nonlinear kinetics and a half-life of 11 to 17 days.
  • With maximal suppression of PCSK9 occurring within 4 hours, peak reduction of LDL-C, ranging from 55 to 75%, occurs ~1-2 weeks after a dose of evolocumab.
  • Patient-specific factors do not have a clinically meaningful effect on the pharmacodynamic effects of evolocumab; thus, no dose adjustment is necessary based on patient-specific factors of concomitant medication use.
  • When combined with a statin, evolocumab can result in additional lowering of LDL-C.


Kasichayanula S, Grover A, Emery MG, et al. Clinical pharmacokinetics and pharmacodynamics of evolocumab, a PCSK9 inhibitor. [Published online ahead of print January 20, 2018]. Clin Pharmacokinet. doi:10.1007/s40262-017-0620-7.

This Week's Must Reads

Anticoagulation in Patients with AF and HF, Clin Cardiol; ePub 2018 Dec 23; Contreras, et al

Serum Uric Acid, Silent MI & Mortality, Am J Cardiol; ePub 2018 Dec 19; Ahmad, et al

Catheter Ablation for AF in Adults with CHD, Heart Rhythm; ePub 2018 Dec 26; Liang, et al

Cognitive Impairment in Adults with Incident HF, J Card Fail; ePub 2018 Dec 22; Sterling, et al

LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

Must Reads in Hypercholesterolemia

LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

Hypertriglyceridemia in Statin-Treated Adults, J Clin Lipidol; ePub 2018 Dec 1; Fan, et al

AHA Statement: Statin Safety & Adverse Events, Arterioscler Thromb Vasc Biol; ePub 2018 Dec 10; Newman, et al

LDL-C Reduction & Arterial Wall Inflammation, Eur Heart J; ePub 2018 Dec 18; Stiekema, et al

Holiday Season and Risk of Hypercholesterolemia, Atherosclerosis; ePub 2018 Dec 19; Vedel-Krogh, et al