Clinical Edge

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Changes in Statin Adherence After an AMI

After an acute myocardial infarction (AMI), patients with increased statin adherence had a similar risk of mortality compared with patients who were continuously adherent, while those with decreased adherence had the worst mortality outcomes, a new study found. The study cohort included patients aged >66 years with an AMI hospitalization from 2009 to 2010. Statin adherence was measured for 180 days pre-AMI, 180 days post-AMI and categorized as severely nonadherent, moderately nonadherent, or adherent. Patients were then followed-up for up to 18 months for all-cause mortality. Among the findings:

  • Of 101,011 eligible patients, 20% had a categorial increase in adherence, 16% decreased, and 14% remained nonadherent both pre- and post-AMI.
  • Patients whose adherence increased had a similar risk of all-cause mortality compared to those who were always adherent.
  • Patients who decreased their statin adherence had a similar or higher risk of all-cause mortality than those who were always severely nonadherent.


Hickson RP, Robinson JG, Annis IE, Killeya-Jones LA, Fang G. It’s not too late to improve statin adherence: Association between changes in statin adherence from before to after and acute myocardial infarction and all-cause mortality. [Published online ahead of print March 30, 2019]. J Am Heart Assoc. doi:10.1161/JAHA.118.011378.