Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Can Plant-Based Diets Treat Hypercholesterolemia?

Clin Cardiol; ePub 2018 Mar 25; Najjar, et al

A plant-based diet may be used as part of an effective therapeutic strategy in the clinical setting to lessen cardiovascular (CV) risk factors, including hypercholesterolemia and hypertension, a recent study suggests. The study examined the implementation of a defined, plant-based diet for 4 weeks in an outpatient clinical setting in 31 participants (aged 32 to 69 years). Participants consumed raw fruits, vegetables, seeds, and avocado and all animal products were excluded from the diet. Medication needs were assessed weekly. Researchers found:

  • Significant reductions were observed for systolic and diastolic blood pressure, serum lipids, and total medication usage.
  • Other CVD risk factors, including weight, waist circumference, heart rate, insulin, glycated hemoglobin, and high-sensitivity C-reactive protein, were also reduced.


Najjar RS, Moore CE, Montgomery BD. A defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications. [Published online ahead of print March 25, 2018]. Clin Cardiol. doi:10.1002/clc.22863.

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Must Reads in Hypercholesterolemia

LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al

Hypertriglyceridemia in Statin-Treated Adults, J Clin Lipidol; ePub 2018 Dec 1; Fan, et al

AHA Statement: Statin Safety & Adverse Events, Arterioscler Thromb Vasc Biol; ePub 2018 Dec 10; Newman, et al

LDL-C Reduction & Arterial Wall Inflammation, Eur Heart J; ePub 2018 Dec 18; Stiekema, et al

Holiday Season and Risk of Hypercholesterolemia, Atherosclerosis; ePub 2018 Dec 19; Vedel-Krogh, et al