Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Exercise Training Workloads in Patients with HF

Am Heart J; ePub 2018 Jul 10; Keteyian, et al

Among a diverse cohort of patients with heart failure (HF), an easily accessible measure of exercise capacity (metabolic equivalents of task [MET]) that is collected during cardiac rehabilitation (CR) is independently associated with the adjusted risk for both all-cause mortality and HF-specific hospitalization. Patients with HF who participated in an early outpatient program were included in the retrospective analysis. Exercise workloads upon entry and completion of CR were converted to METs. The primary outcome was all-cause mortality and the secondary outcome was HF hospitalization. Researchers found:

  • Among 707 patients, the median exercise training workload at the start and end of CR was 2.5 METs and 3.2 METs, respectively, for men and 2.2 METs and 2.9 METs, respectively, for women.
  • There were 242 deaths and 266 hospitalizations.
  • METs achieved at the end of CR had the strongest independent association with all-cause mortality (adjusted HR, 0.58) and HF hospitalization (adjusted HR, 0.62).
  • Each one 1 MET higher workload at the end of CR was associated with a 42% and 38% lower adjusted risk for all-cause mortality and HF hospitalization.


Keteyian SJ, Kerrigan DJ, Lewis B, Ehrman JK, Brawner CA. Exercise training workloads in cardiac rehabilitation are associated with clinical outcomes in patients with heart failure. [Published online ahead of print July 10, 2018]. Am Heart J. doi:10.1016/j.ahj.2018.05.017.

This Week's Must Reads

Trends in LDL-C and 2013 Treatment Guidelines, Clin Cardiol; ePub 2018 Nov 15; Superko, et al

PCSK9 Inhibitors Reduce Risk of CV Events, Nat Rev Cardiol; ePub 2018 Nov 12; Sabatine, et al

Risk Factors for CVD in Heterozygous FH, J Clin Lipidol; ePub 2018 Nov 7; Akioyamen, et al

Hypercholesterolemia Patients on Suboptimal Statins, J Atheroscler Thromb; ePub 2018 Oct 26; Kajinami, et al

Cholesterol Guidelines Stress Lifetime Approach, Circulation; ePub 2018 Nov 10; Grundy, et al

Must Reads in Heart Failure

“Food Deserts” & Hospitalization in Patients with HF, Am J Cardiol; ePub 2018 Oct 18; Morris, et al

Timing of ICD Placement From Last Hospitalization for HF, Circulation; ePub 2018 Sep 13; Ambrosy, et al

Outcomes in Patients with Alcoholic Cardiomyopathy, Clin Cardiol; ePub 2018 Sep 4; Ram, et al

PIs and CV Outcomes in Patients with HIV and HF, J Am Coll Cardiol; 2018 Jul; Alvi, Neilan, et al

Exercise Training Workloads in Patients with HF, Am Heart J; ePub 2018 Jul 10; Keteyian, et al