Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Obesity Ups Type 2 Diabetes Risk Far More Than Lifestyle, Genetics

Key clinical point: Obesity has a dominant effect on the risk of type 2 diabetes over other risk factors, highlighting the importance of weight management in prevention.

Major finding: Obesity was associated with a 480% increased risk of incident type 2 diabetes regardless of genetic risk status.

Study details: A Danish population-based, case-cohort study of 9,556 participants, half with incident type 2 diabetes.

Disclosures: The Diet, Cancer, and Health cohort is supported by the Danish Cancer Society. The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation. Ms. Jakupovic and associates are funded either directly or indirectly by the Novo Nordisk Foundation.


Jakupovic H et al. EASD 2019, Abstract 376.