Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

No Reduction in PE Risk With Vena Cava Filters After Severe Injury

Key clinical point: Vena cava filters may not reduce pulmonary embolism risk after severe injury.

Major finding: The incidence of pulmonary embolism and death at 90 days was similar in patients with vena cava filters and those without (13.9% vs. 14.4% respectively, P = 0.98).

Study details: A multicenter, randomized controlled trial of 240 patients with severe injury.

Disclosures: The Medical Research Foundation of Royal Perth Hospital and the Western Australian Department of Health funded the study. Dr. Ho reported funding from the Western Australian Department of Health and the Raine Medical Research Foundation to conduct the study, as well as serving as an adviser to Medtronic and Cardinal Health.


Ho KM et al. N Engl J Med. 2019 Jul 7. doi: 10.156/NEJMoa1806515.