Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Polygenic risk score helps target AAA screening

Key clinical point: A 29-item genetic risk score improved the screening pick-up rate for abdominal aortic aneurysms when used with age and sex.

Major finding: The polygenic risk score identified an AAA prevalence of 8.6% in men aged older than 50 years.

Study details: Researchers used data collected in the Million Veteran Program to derive the polygenic risk score.

Disclosures: The study had no commercial funding. Dr. Klarin has been a consultant to Regeneron.


Klarin D et al. Vascular Discovery 2020, abstract 170.