Key clinical point: Drugs commonly used to treat multiple myeloma carry cardiovascular risks that should be carefully monitored.
Major finding: Cardiovascular adverse events occurred in 33 of the 65 patients (51%) randomized to carfilzomib, compared with 5 of 30 patients (17%) assigned to bortezomib.
Study details: The ongoing PROTECT trial enrolled 95 patients with relapsed multiple myeloma and randomized them to receive carfilzomib or bortezomib.
Disclosures: The PROTECT study is sponsored by Millennium Pharmaceuticals. Dr. Cornell reported having no financial disclosures.
REPORTING FROM ACC CARDIO-ONCOLOGY
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Income Volatility & Elevated Risk of CVD, Circulation; ePub 2019 Jan 7; Elfassy, et al