Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Mechanical circulatory support in PCI needs clearer guidance

Key clinical point: Outcomes for Impella mechanical circulatory support during percutaneous coronary interventions are variable.

Major finding: Impella mortality was 32% higher than with intra-aortic balloon pumps.

Data source: An analysis of 28,304 patients with acute MI and cardiogenic shock in the National Cardiovascular Data Registry’s CathPCI and Chest Pain–MI registries; and an observational analysis of 48,306 percutaneous coronary intervention patients in the Premier Healthcare Database.

Disclosures: Dr. Amin disclosed relationships with Terumo and GEO Healthcare. Dr. Dhruva has no relationships to disclose. The study was supported in part by a Center of Excellence in Regulatory Science and Innovation grant from the Food and Drug Administration and the American College of Cardiology’s National Cardiovascular Data Registry.


Amin AP, Dhruva S. AHA 2019, Late-Breaking Science 4 session.