Clinical Edge

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HFpEF: Gender difference in sacubitril/valsartan response remains mystery

Key clinical point: The marked gender difference in HFpEF clinical outcomes in response to sacubitril/valsartan has nothing to do with the medication’s impact on NT-proBNP.

Major finding: Women on sacubitril/valsartan get a 27% reduction in cardiovascular death and heart failure hospitalization.

Study details: This double-blind, randomized, multicenter trial included nearly 5,000 HFpEF patients assigned to sacubitril/valsartan or valsartan and followed for a median of 34 months.

Disclosures: The presenter reported no financial conflicts regarding the Novartis-funded PARAGON-HF trial.


Cunningham JW. ACC 2020, Abstract 412-08.