Clinical Edge

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FUEL trial: Post-Fontan udenafil shows mixed results

Key clinical point: Udenafil improved exercise performance in adolescents after Fontan palliation.

Major finding: Peak oxygen consumption levels declined 0.23 and 0.89 mL/kg per minute on udenafil and placebo, respectively (P = 0.092).

Study details: Pediatric Heart Network’s Fontan Udenafil Exercise Longitudinal (FUEL) trial of 400 patients randomized to udenafil or placebo.

Disclosures: Dr. Goldberg disclosed receiving research grants from trial sponsor Mezzion and the National Heart, Lung, and Blood Institute.


Goldberg D. AHA 2019, Late Breaking Science Session 5.