Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

First-time marathon runners rewind the clock on vascular aging

Key clinical point: Individuals who trained for a marathon showed improvement in age-related aortic stiffness and reduction in blood pressure.

Major finding: Compared with pretraining values, the descending aortas of marathon completers were 9% more distensible at the level of the bifurcation of the pulmonary artery and 16% more distensible at the level of the diaphragm (P = .0009 and .002, respectively).

Study details: A prospective cohort study of 138 first-time completers of the London Marathon.

Disclosures: The study was funded by the British Heart Foundation, Cardiac Risk in the Young, and the Barts Cardiovascular Biomedical Research Centre. Exercise testing equipment and technical support were provided by COSMED. Dr. Bhuva reported receiving funding from the British Heart Foundation. Dr. Chirinos reported having been a consultant or receiving research funding from multiple pharmaceutical companies and Microsoft; he is also an inventor of University of Pennsylvania–held patents for cardiovascular pharmaceutical agents.


Bhuva A et al. J Am Coll Cardiol. 2020 Jan;75(1):60-71.