Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug

Key clinical point: Dapagliflozin produced multiple, statistically significant benefits in heart failure patients on top of guideline-directed therapy.

Major finding: The study’s primary endpoint fell by a statistically significant 27% with dapagliflozin compared with placebo in patients without diabetes.

Study details: DAPA-HF, a multinational study with 4,744 patients at 410 sites.

Disclosures: DAPA-HF was sponsored by AstraZeneca, the company that markets dapagliflozin (Farxiga). AstraZeneca paid Glasgow University to cover Dr. McMurray’s salary during the time he spent working as principal investigator of DAPA-HF.


Annual congress of the European Society of Cardiology, 2019