Clinical Edge

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CREOLE: Amlodipine may be preferable for lowering blood pressure in black patients

Key clinical point: The combinations of amlodipine and either hydrochlorothiazide or perindopril were effective in reducing blood pressure in black African patients.

Major finding: Compared to perindopril plus hydrochlorothiazide, amlodipine plus hydrochlorothiazide led to an additional -3.14 mm Hg reduction from baseline (95% CI, -5.90 to -0.38, P = 0.03) and amlodipine plus perindopril led to an additional -3.00 mm Hg reduction (95% CI, -5.81 to -0.20, P = 0.04).

Study details: A randomized, single-blind, three-group trial of 728 black patients from sub-Saharan Africa with uncontrolled hypertension.

Disclosures: The study was sponsored by a grant from the GlaxoSmithKline Africa Noncommunicable Disease Open Lab. Trial drugs were donated by Aspen Pharmacare. Two authors reported receiving grants and personal fees from numerous pharmaceutical companies.


Ojji DB et al. NEJM. 2019 Mar 18. doi: 10.1056/NEJMoa1901113.