Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Noninvasive FFRCT called ADVANCE in chest pain assessment

Key clinical point: Fractional flow reserve derived noninvasively from coronary CT angiography (FFRCT) showed value for evaluation of chest pain in real-world clinical practice.

Major finding: The composite of cardiovascular death or MI at 1 year was 320% more common in patients whose management was guided by an FFRCT value greater than 0.80 than in those with a lesser value.

Study details: The observational, prospective ADVANCE registry includes more than 5,000 patients with clinically suspected obstructive coronary artery disease who underwent noninvasive assessment via coronary CT angiography coupled with fractional flow reserve measurement using computational fluid dynamics.

Disclosures: The registry is supported by HeartFlow. The presenter reported receiving research grants from that company and several others as well as the National Institutes of Health.