Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lung Function & CVD Risk in Patients with MetS & DM

Clin Cardiol; ePub 2018 May 24; Lee, et al

In patients with and without metabolic syndrome (MetS), 1 second forced expiratory volume (FEV1) and forced vital capacity (FVC) are inversely related to cardiovascular disease (CVD), but not diabetes mellitus (DM) in older adults. Researchers followed 4,114 participants aged ≥65 years in the Cardiovascular Health Study with and without MetS or DM and examined the association of FVC and FEV1 with incident coronary heart disease (CHD) and CVD events over 12.9 years. They found:

  • DM was present in 537 (13.1%) and MetS in 1,277 (31.0%) participants.
  • Comparing the 4th vs 1st quartiles for FVC, the risk of CVD events was 16%, 23%, and 30% lower in DM, MetS, and neither disease groups, respectively.
  • For FEV1, CVD risk was lower by 2%, 26%, and 31% in DM, respectively.
  • Findings were strongest for predicting chronic heart failure (CHF) in all disease groups.


Lee HM, Zhao Y, Liu MA, et al. Impact off lung function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes. [Published online ahead of print May 24, 2018]. Clin Cardiol. doi:10.1002/clc.22985.

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