The effects of fixed-dose combination therapy on all-cause mortality and fatal and nonfatal heart attacks and strokes are uncertain; however, modest increases in adverse events were observed when compared to placebo. This according to an updated review that included 4 studies (n=2,102 participants, mean age range 62-63 years) with individuals with a prior heart attack or stroke or with a high predicted risk for having an initial heart attack and 5 studies that had long-term follow-up (≥12 months). Most participants were middle-aged men with moderate elevations in blood pressure (BP) or cholesterol. The fixed-dose combinations ranged from 2 to 5 drugs; all studies included at least 1 BP-lowering and 1 cholesterol-lowering drug. Researchers found:
- The effects of fixed-dose combination drug therapy on all-cause mortality and fatal and nonfatal heart attacks and strokes are uncertain.
- Fixed-dose combination drug therapy leads to more adverse events than control (32% vs 27%), including placebo.
- Fixed-dose combination therapy may modestly lower BP and cholesterol and appears to improve adherence to medications to prevent ASCVD.
Bahiru E, de Cates AN, Farr MRB, et al. Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular diseases. Cochrane Database of Systematic Reviews 2017, Issue 3. Art. No.:CD009868. doi:10.1002/14651858.CD009868.pub3.
This Week's Must Reads
Anticoagulation in Patients with AF and HF, Clin Cardiol; ePub 2018 Dec 23; Contreras, et al
Serum Uric Acid, Silent MI & Mortality, Am J Cardiol; ePub 2018 Dec 19; Ahmad, et al
Catheter Ablation for AF in Adults with CHD, Heart Rhythm; ePub 2018 Dec 26; Liang, et al
Cognitive Impairment in Adults with Incident HF, J Card Fail; ePub 2018 Dec 22; Sterling, et al
LDL-C Level Reduction Consistent with Evolocumab , JAMA Cardiol; ePub 2018 Dec 12; Qamar, et al
Must Reads in CAD & Atherosclerosis
Myocardial Infarction Incidence in Patients with PAD, JAMA Cardiol; ePub 2018 Dec 12; Olivier, et al
Healthy Lifestyle During Midlife & Subclinical Atherosclerosis, J Am Heart Assoc; ePub 2018 Nov 28; Wang, et al
Sedentary Lifestyle and Increased CVD Risk , Am J Cardiol; ePub 2018 Dec 3; Mainous III, et al
CAD Severity as a Function of Patient Sex, Am Heart J; ePub 2018 Oct 2; Pagidipati, et al
Does Aspirin Prevent CV Events in Older Adults?, N Engl J Med; ePub 2018 Sep 16; McNeil, et al